Kristin Grußmayer

I am a biophysicist with extensive experience in working with custom-built microscopes and quantitative analysis of single-molecule data. This includes a strong command of statistical data analysis, biochemistry skills such as protein and DNA labeling and expertise in controlling dye photophysics. I am currently working at the EPFL, extending my quantitative microscopy expertise to 3D super-resolution and phase imaging. As a Horizon 2020 Marie Sklodowska Curie fellow, I aim at bridging neurobiology and life science with advanced microscopy and image analysis for the direct monitoring of Parkinson compromised neurons to uncover the underlying molecular mechanism.

A neuron with Alexa647-labeled alpha-synuclein

A primary hippocampal neuron from mice treated with alpha-synuclein fibrils. The second order SOFI image (left) shows newly formed alpha-synuclein aggregates with color-coded z-position. The neuron cell body can be seen in a 2d phase image slice (right). The center image shows an overlay of both images. Both images were taken in a single multi-plane microscope in the lab of Prof. T. Lasser in collaboration with the group of Prof. H. Lashuel.

Conjugated polymers

A unique way of investigating the photophysics of conjugated polymers by looking at the statistics of photon emission. The plot show the changing emitter number and brightness of a single poly(3-hexylthiophene) chain over time. The data was taken during my doctorate in the group of Prof. D.-P. Herten in collaboration with the group of Prof. J. Lupton. DOI: 10.1002/cphc.201500719